Drug interactions
Cyclosporin + Talquetamab
Severity: Moderate
Cyclosporin and Talquetamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Talquetamab causes cytokine release that can suppress CYP enzymes, temporarily raising cyclosporine exposure. This risks cyclosporine toxicity such as nephrotoxicity and neurotoxicity.
What this interaction means in plain words
Cyclosporin and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Talquetamab belongs to Oncology.
Why it happens
Cytokines released by talquetamab downregulate CYP3A4, reducing cyclosporine metabolism.
What to do
Monitor cyclosporine concentrations and renal function during step-up dosing and for about two weeks after the first treatment dose, and during any CRS. Adjust the cyclosporine dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Talquetamab
- Clozapine + Talquetamab Major
- Pimozide + Talquetamab Major
- Bendamustine + Talquetamab Moderate
- Carbamazepine + Talquetamab Moderate
- Clomipramine + Talquetamab Moderate
- Colchicine + Talquetamab Moderate
Frequently asked questions
Can I take Cyclosporin with Talquetamab?
MediHelp rates the interaction as moderate. Cyclosporin and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Talquetamab causes cytokine release that can suppress CYP enzymes, temporarily raising cyclosporine exposure. This risks cyclosporine toxicity such as nephrotoxicity and neurotoxicity.
How serious is the interaction between Cyclosporin and Talquetamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine concentrations and renal function during step-up dosing and for about two weeks after the first treatment dose, and during any CRS. Adjust the cyclosporine dose accordingly.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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