Drug interactions
Cobicistat + Eszopiclone
Severity: Moderate
Cobicistat and Eszopiclone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a strong CYP3A inhibitor and can substantially raise eszopiclone exposure. This may cause excessive sedation, confusion and psychomotor impairment.
What this interaction means in plain words
Cobicistat and Eszopiclone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cobicistat belongs to Miscellaneous; Eszopiclone belongs to Central Nervous System.
Why it happens
Strong inhibition of CYP3A4 by cobicistat reduces eszopiclone clearance.
What to do
Limit eszopiclone to a 1 mg starting dose with a maximum of 2 mg. Monitor for oversedation and consider an alternative hypnotic if effects are excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Eszopiclone?
MediHelp rates the interaction as moderate. Cobicistat and Eszopiclone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat is a strong CYP3A inhibitor and can substantially raise eszopiclone exposure. This may cause excessive sedation, confusion and psychomotor impairment.
How serious is the interaction between Cobicistat and Eszopiclone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit eszopiclone to a 1 mg starting dose with a maximum of 2 mg. Monitor for oversedation and consider an alternative hypnotic if effects are excessive.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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