Drug interactions
Cobicistat + Hydrochlorothiazide-losartan
Severity: Minor
Cobicistat and Hydrochlorothiazide-losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a strong CYP3A4 inhibitor and may raise losartan exposure. Losartan is converted to its active metabolite mainly by CYP2C9 and CYP3A4, so the net clinical change is uncertain and probably modest.
What this interaction means in plain words
Cobicistat and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cobicistat belongs to Miscellaneous; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated losartan metabolism, which may alter the ratio of parent drug to active metabolite.
What to do
Monitor blood pressure and adjust the losartan dose according to response when cobicistat is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as minor. Cobicistat and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cobicistat is a strong CYP3A4 inhibitor and may raise losartan exposure. Losartan is converted to its active metabolite mainly by CYP2C9 and CYP3A4, so the net clinical change is uncertain and probably modest.
How serious is the interaction between Cobicistat and Hydrochlorothiazide-losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adjust the losartan dose according to response when cobicistat is started or stopped.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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