Drug interactions
Cobicistat + Roflumilast
Severity: Moderate
Cobicistat and Roflumilast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat may raise roflumilast exposure, increasing the risk of adverse effects such as diarrhea, weight loss, insomnia, headache and psychiatric symptoms.
What this interaction means in plain words
Cobicistat and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cobicistat belongs to Miscellaneous; Roflumilast belongs to Respiratory.
Why it happens
Cobicistat is a strong CYP3A4 inhibitor and reduces roflumilast clearance.
What to do
Monitor for diarrhea, weight loss and neuropsychiatric symptoms, and consider stopping roflumilast if these become troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Roflumilast
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Roflumilast?
MediHelp rates the interaction as moderate. Cobicistat and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat may raise roflumilast exposure, increasing the risk of adverse effects such as diarrhea, weight loss, insomnia, headache and psychiatric symptoms.
How serious is the interaction between Cobicistat and Roflumilast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diarrhea, weight loss and neuropsychiatric symptoms, and consider stopping roflumilast if these become troublesome.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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