Drug interactions
Cobicistat + Rosuvastatin
Severity: Moderate
Cobicistat and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat modestly raises rosuvastatin exposure, mainly through transporter inhibition rather than CYP3A4, since rosuvastatin is little metabolized. This may increase the risk of myopathy.
What this interaction means in plain words
Cobicistat and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cobicistat belongs to Miscellaneous; Rosuvastatin belongs to Cardiovascular.
Why it happens
Inhibition of intestinal and hepatic transporters (such as OATP1B1 and BCRP) by cobicistat raises rosuvastatin levels.
What to do
Use the lowest effective rosuvastatin dose and keep it at or below 20 mg daily. Monitor for muscle symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosuvastatin
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Rosuvastatin?
MediHelp rates the interaction as moderate. Cobicistat and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat modestly raises rosuvastatin exposure, mainly through transporter inhibition rather than CYP3A4, since rosuvastatin is little metabolized. This may increase the risk of myopathy.
How serious is the interaction between Cobicistat and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective rosuvastatin dose and keep it at or below 20 mg daily. Monitor for muscle symptoms.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporin, Darolutamide. The full list is on the Rosuvastatin page.
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