Drug interactions
Cobicistat + Saxagliptin-metformin
Severity: Moderate
Cobicistat and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a strong CYP3A4 inhibitor and markedly raises saxagliptin exposure. Saxagliptin labeling restricts its dose with strong CYP3A4 inhibitors.
What this interaction means in plain words
Cobicistat and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cobicistat belongs to Miscellaneous; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Cobicistat inhibits CYP3A4/5-mediated metabolism of saxagliptin.
What to do
Limit saxagliptin to 2.5 mg once daily; note the fixed-dose saxagliptin-metformin product may not permit this, so use separate components or an alternative. Monitor glucose and adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Cobicistat and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat is a strong CYP3A4 inhibitor and markedly raises saxagliptin exposure. Saxagliptin labeling restricts its dose with strong CYP3A4 inhibitors.
How serious is the interaction between Cobicistat and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit saxagliptin to 2.5 mg once daily; note the fixed-dose saxagliptin-metformin product may not permit this, so use separate components or an alternative. Monitor glucose and adverse effects.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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