Drug interactions
Cobicistat + Terbinafine
Severity: Minor
Cobicistat and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a potent CYP3A4 inhibitor that may modestly raise terbinafine levels. Because CYP3A4 is a minor clearance route for terbinafine, the effect is likely small.
What this interaction means in plain words
Cobicistat and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cobicistat belongs to Miscellaneous; Terbinafine belongs to Anti Fungals.
Why it happens
Cobicistat inhibits CYP3A4, a minor pathway of terbinafine metabolism.
What to do
No empirical dose change is required. Monitor for terbinafine adverse effects, including liver enzyme changes, if therapy is prolonged.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Terbinafine?
MediHelp rates the interaction as minor. Cobicistat and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cobicistat is a potent CYP3A4 inhibitor that may modestly raise terbinafine levels. Because CYP3A4 is a minor clearance route for terbinafine, the effect is likely small.
How serious is the interaction between Cobicistat and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is required. Monitor for terbinafine adverse effects, including liver enzyme changes, if therapy is prolonged.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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