Drug interactions
Cobicistat + Umeclidinium-vilanterol
Severity: Moderate
Cobicistat and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a strong CYP3A4 inhibitor and can increase systemic vilanterol exposure. This may enhance cardiovascular effects such as tachycardia, QT prolongation and hypokalemia.
What this interaction means in plain words
Cobicistat and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cobicistat belongs to Miscellaneous; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Cobicistat inhibits CYP3A4 and P-glycoprotein, reducing vilanterol clearance.
What to do
Monitor for tachycardia, palpitations, tremor and low potassium. Consider an alternative bronchodilator if symptoms of beta-agonist excess occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Cobicistat and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat is a strong CYP3A4 inhibitor and can increase systemic vilanterol exposure. This may enhance cardiovascular effects such as tachycardia, QT prolongation and hypokalemia.
How serious is the interaction between Cobicistat and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tachycardia, palpitations, tremor and low potassium. Consider an alternative bronchodilator if symptoms of beta-agonist excess occur.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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