Drug interactions
Cobimetinib + Crizotinib
Severity: Major
Cobimetinib and Crizotinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a moderate CYP3A4 inhibitor and may increase cobimetinib exposure. This may increase cobimetinib toxicities such as rash, hemorrhage, rhabdomyolysis and liver injury.
What this interaction means in plain words
Cobimetinib and Crizotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cobimetinib belongs to Oncology; Crizotinib belongs to Oncology.
Why it happens
Crizotinib inhibits CYP3A4, decreasing cobimetinib metabolism.
What to do
Use an alternative if possible; otherwise follow cobimetinib labeling for dose reduction and monitor for adverse effects, including CK and liver enzymes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Cobimetinib
- Cobimetinib + Efavirenz Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Amobarbital + Cobimetinib Major
- Apalutamide + Cobimetinib Major
- Aprepitant + Cobimetinib Major
- Bosentan + Cobimetinib Major
Frequently asked questions
Can I take Cobimetinib with Crizotinib?
MediHelp rates the interaction as major. Cobimetinib and Crizotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Crizotinib is a moderate CYP3A4 inhibitor and may increase cobimetinib exposure. This may increase cobimetinib toxicities such as rash, hemorrhage, rhabdomyolysis and liver injury.
How serious is the interaction between Cobimetinib and Crizotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative if possible; otherwise follow cobimetinib labeling for dose reduction and monitor for adverse effects, including CK and liver enzymes.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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