Drug interactions
Cobimetinib + Dronedarone
Severity: Major
Cobimetinib and Dronedarone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone, a moderate CYP3A4 inhibitor, may increase cobimetinib exposure. This raises the risk of adverse effects such as hemorrhage, rhabdomyolysis, serous retinopathy and liver toxicity.
What this interaction means in plain words
Cobimetinib and Dronedarone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cobimetinib belongs to Oncology; Dronedarone belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated metabolism of cobimetinib.
What to do
Prefer an alternative to dronedarone. If short-term use is unavoidable, reduce the cobimetinib dose per labeling and monitor for toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Cobimetinib
- Cobimetinib + Efavirenz Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Amobarbital + Cobimetinib Major
- Apalutamide + Cobimetinib Major
- Aprepitant + Cobimetinib Major
- Bosentan + Cobimetinib Major
Frequently asked questions
Can I take Cobimetinib with Dronedarone?
MediHelp rates the interaction as major. Cobimetinib and Dronedarone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dronedarone, a moderate CYP3A4 inhibitor, may increase cobimetinib exposure. This raises the risk of adverse effects such as hemorrhage, rhabdomyolysis, serous retinopathy and liver toxicity.
How serious is the interaction between Cobimetinib and Dronedarone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative to dronedarone. If short-term use is unavoidable, reduce the cobimetinib dose per labeling and monitor for toxicity.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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