Drug interactions
Cobimetinib + Ribociclib
Severity: Moderate
Cobimetinib and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobimetinib is a CYP3A4 substrate, and ribociclib inhibits CYP3A4, so cobimetinib exposure may increase. This may heighten adverse effects such as hemorrhage, rhabdomyolysis, retinopathy and liver toxicity.
What this interaction means in plain words
Cobimetinib and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cobimetinib belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibition of CYP3A4 reduces cobimetinib metabolism.
What to do
Avoid if alternatives exist; otherwise monitor for cobimetinib toxicity and consider dose reduction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Cobimetinib
- Cobimetinib + Efavirenz Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Amobarbital + Cobimetinib Major
- Apalutamide + Cobimetinib Major
- Aprepitant + Cobimetinib Major
- Bosentan + Cobimetinib Major
Frequently asked questions
Can I take Cobimetinib with Ribociclib?
MediHelp rates the interaction as moderate. Cobimetinib and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobimetinib is a CYP3A4 substrate, and ribociclib inhibits CYP3A4, so cobimetinib exposure may increase. This may heighten adverse effects such as hemorrhage, rhabdomyolysis, retinopathy and liver toxicity.
How serious is the interaction between Cobimetinib and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if alternatives exist; otherwise monitor for cobimetinib toxicity and consider dose reduction.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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