Drug interactions
Cocaine + Ribociclib
Severity: Minor
Cocaine and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topical cocaine is used locally with limited systemic absorption, and its metabolism is mainly through esterases rather than CYP3A4. A meaningful interaction with ribociclib is not expected.
What this interaction means in plain words
Cocaine and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cocaine belongs to Central Nervous System; Ribociclib belongs to Oncology.
Why it happens
Cocaine undergoes minor CYP3A4 N-demethylation, so any effect of ribociclib is likely small.
What to do
No action is needed for topical use. Monitor cardiovascular status if large amounts are absorbed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Cocaine
- Cocaine + Isocarboxazid Contraindicated
- Cocaine + Phenelzine Contraindicated
- Cocaine + Procarbazine Contraindicated
- Amitriptyline + Cocaine Major
- Bisoprolol + Cocaine Major
- Citalopram + Cocaine Major
Frequently asked questions
Can I take Cocaine with Ribociclib?
MediHelp rates the interaction as minor. Cocaine and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Topical cocaine is used locally with limited systemic absorption, and its metabolism is mainly through esterases rather than CYP3A4. A meaningful interaction with ribociclib is not expected.
How serious is the interaction between Cocaine and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed for topical use. Monitor cardiovascular status if large amounts are absorbed.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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