Drug interactions
Cocaine + Zolmitriptan
Severity: Minor
Cocaine and Zolmitriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topical cocaine has limited systemic absorption, but it blocks monoamine reuptake and could theoretically add serotonergic and vasoconstrictive effects to zolmitriptan.
What this interaction means in plain words
Cocaine and Zolmitriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cocaine belongs to Central Nervous System; Zolmitriptan belongs to Central Nervous System.
Why it happens
Theoretical additive serotonergic and vasoconstrictive effects.
What to do
No routine change is needed with limited topical use; watch for serotonin toxicity or chest pain if heavily used. Avoid triptans after illicit cocaine use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Other interactions of Cocaine
- Cocaine + Isocarboxazid Contraindicated
- Cocaine + Phenelzine Contraindicated
- Cocaine + Procarbazine Contraindicated
- Amitriptyline + Cocaine Major
- Bisoprolol + Cocaine Major
- Citalopram + Cocaine Major
Frequently asked questions
Can I take Cocaine with Zolmitriptan?
MediHelp rates the interaction as minor. Cocaine and Zolmitriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Topical cocaine has limited systemic absorption, but it blocks monoamine reuptake and could theoretically add serotonergic and vasoconstrictive effects to zolmitriptan.
How serious is the interaction between Cocaine and Zolmitriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed with limited topical use; watch for serotonin toxicity or chest pain if heavily used. Avoid triptans after illicit cocaine use.
What other medicines interact with Zolmitriptan?
MediHelp also lists interactions of Zolmitriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Zolmitriptan page.
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