Drug interactions
Codeine + Eluxadoline
Severity: Moderate
Codeine and Eluxadoline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline is a mu-opioid agonist used for diarrhea-predominant IBS and can cause constipation and pancreatitis. Codeine's constipating effect adds to this and raises the risk of severe constipation complications.
What this interaction means in plain words
Codeine and Eluxadoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Codeine belongs to Musculoskeletal; Eluxadoline belongs to Gastrointestinal Tract.
Why it happens
Additive mu-opioid receptor-mediated reduction in gastrointestinal motility.
What to do
Avoid regular use of codeine with eluxadoline where possible. If used, monitor for constipation and stop eluxadoline if severe constipation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Eluxadoline
Frequently asked questions
Can I take Codeine with Eluxadoline?
MediHelp rates the interaction as moderate. Codeine and Eluxadoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eluxadoline is a mu-opioid agonist used for diarrhea-predominant IBS and can cause constipation and pancreatitis. Codeine's constipating effect adds to this and raises the risk of severe constipation complications.
How serious is the interaction between Codeine and Eluxadoline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular use of codeine with eluxadoline where possible. If used, monitor for constipation and stop eluxadoline if severe constipation develops.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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