Drug interactions
Codeine + Haloperidol
Severity: Moderate
Codeine and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol adds sedation and CNS depression to codeine and is a CYP2D6 substrate and inhibitor that may somewhat reduce activation of codeine to morphine. The result may be oversedation or reduced analgesia.
What this interaction means in plain words
Codeine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Codeine belongs to Musculoskeletal; Haloperidol belongs to Central Nervous System.
Why it happens
Additive CNS depression plus CYP2D6 inhibition that may reduce morphine formation.
What to do
Monitor for sedation and respiratory depression and for adequacy of pain relief. Consider a non-CYP2D6-dependent opioid if analgesia is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Codeine with Haloperidol?
MediHelp rates the interaction as moderate. Codeine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol adds sedation and CNS depression to codeine and is a CYP2D6 substrate and inhibitor that may somewhat reduce activation of codeine to morphine. The result may be oversedation or reduced analgesia.
How serious is the interaction between Codeine and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression and for adequacy of pain relief. Consider a non-CYP2D6-dependent opioid if analgesia is poor.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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