Drug interactions
Codeine + Iloperidone
Severity: Moderate
Codeine and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone can cause sedation and orthostatic hypotension, which may be worsened by codeine. Iloperidone is also partly metabolized by CYP2D6 and has QT effects, but the main concern is additive CNS depression.
What this interaction means in plain words
Codeine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Codeine belongs to Musculoskeletal; Iloperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotension from opioid agonism and antipsychotic receptor antagonism.
What to do
Monitor sedation and blood pressure, particularly during dose initiation, and counsel patients about rising slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Codeine with Iloperidone?
MediHelp rates the interaction as moderate. Codeine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone can cause sedation and orthostatic hypotension, which may be worsened by codeine. Iloperidone is also partly metabolized by CYP2D6 and has QT effects, but the main concern is additive CNS depression.
How serious is the interaction between Codeine and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure, particularly during dose initiation, and counsel patients about rising slowly.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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