Drug interactions
Codeine + Mirabegron
Severity: Minor
Codeine and Mirabegron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Codeine is a prodrug activated to morphine by CYP2D6, so inhibition of this enzyme by mirabegron may lower morphine formation. The analgesic effect may be reduced, though the inhibition is modest.
What this interaction means in plain words
Codeine and Mirabegron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Codeine belongs to Musculoskeletal; Mirabegron belongs to Genitourinary.
Why it happens
Mirabegron inhibits CYP2D6, reducing conversion of codeine to morphine.
What to do
Assess pain control after mirabegron is started and switch to a non-CYP2D6-dependent analgesic if the response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Frequently asked questions
Can I take Codeine with Mirabegron?
MediHelp rates the interaction as minor. Codeine and Mirabegron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Codeine is a prodrug activated to morphine by CYP2D6, so inhibition of this enzyme by mirabegron may lower morphine formation. The analgesic effect may be reduced, though the inhibition is modest.
How serious is the interaction between Codeine and Mirabegron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess pain control after mirabegron is started and switch to a non-CYP2D6-dependent analgesic if the response is inadequate.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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