Drug interactions
Codeine + Ribociclib
Severity: Minor
Codeine and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4, which handles a minor pathway of codeine metabolism toward norcodeine. Shunting may modestly raise morphine formation, and the effect is generally small. Ribociclib prolongs the QT interval, but codeine is not a recognized QT-prolonging risk.
What this interaction means in plain words
Codeine and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Codeine belongs to Musculoskeletal; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, altering the minor N-demethylation pathway of codeine.
What to do
No dose adjustment is usually needed; monitor for opioid adverse effects such as sedation and constipation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Codeine with Ribociclib?
MediHelp rates the interaction as minor. Codeine and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ribociclib inhibits CYP3A4, which handles a minor pathway of codeine metabolism toward norcodeine. Shunting may modestly raise morphine formation, and the effect is generally small. Ribociclib prolongs the QT interval, but codeine is not a recognized QT-prolonging risk.
How serious is the interaction between Codeine and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor for opioid adverse effects such as sedation and constipation.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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