Drug interactions
Codeine + Tipranavir
Severity: Minor
Codeine and Tipranavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, given with ritonavir, has complex inhibitory and inducing effects, and ritonavir inhibits CYP2D6. This could reduce conversion of codeine to morphine and alter analgesia, though the effect is not well characterized. The legacy direction of increased effect is doubtful.
What this interaction means in plain words
Codeine and Tipranavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Codeine belongs to Musculoskeletal; Tipranavir belongs to Anti Virals.
Why it happens
Possible CYP2D6 inhibition by the ritonavir-boosted regimen, with CYP3A4 effects altering codeine clearance.
What to do
Monitor analgesic efficacy and signs of opioid toxicity when starting or stopping the antiretroviral regimen.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Codeine with Tipranavir?
MediHelp rates the interaction as minor. Codeine and Tipranavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tipranavir, given with ritonavir, has complex inhibitory and inducing effects, and ritonavir inhibits CYP2D6. This could reduce conversion of codeine to morphine and alter analgesia, though the effect is not well characterized. The legacy direction of increased effect is doubtful.
How serious is the interaction between Codeine and Tipranavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic efficacy and signs of opioid toxicity when starting or stopping the antiretroviral regimen.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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