Drug interactions
Colchicine + Dabrafenib
Severity: Moderate
Colchicine and Dabrafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may lower colchicine levels, making treatment less effective. Colchicine toxicity may emerge if dabrafenib is later withdrawn.
What this interaction means in plain words
Colchicine and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colchicine belongs to Genitourinary; Dabrafenib belongs to Oncology.
Why it happens
Dabrafenib induces CYP3A4, and possibly P-gp, increasing colchicine clearance.
What to do
Monitor for reduced colchicine efficacy and titrate the dose to response. Watch for toxicity after dabrafenib discontinuation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Colchicine with Dabrafenib?
MediHelp rates the interaction as moderate. Colchicine and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may lower colchicine levels, making treatment less effective. Colchicine toxicity may emerge if dabrafenib is later withdrawn.
How serious is the interaction between Colchicine and Dabrafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced colchicine efficacy and titrate the dose to response. Watch for toxicity after dabrafenib discontinuation.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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