Drug interactions
Colchicine + Deferasirox
Severity: Minor
Colchicine and Deferasirox: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox has variable effects on CYP enzymes, mainly inducing CYP3A4 weakly while inhibiting CYP2C8 and CYP1A2. A reduction in colchicine exposure is possible but not well characterized.
What this interaction means in plain words
Colchicine and Deferasirox have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Colchicine belongs to Genitourinary; Deferasirox belongs to Miscellaneous.
Why it happens
Possible weak CYP3A4 induction by deferasirox; the effect on colchicine is not well established.
What to do
Monitor colchicine response and adjust dose only if efficacy is lost. No routine adjustment is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Deferasirox
Frequently asked questions
Can I take Colchicine with Deferasirox?
MediHelp rates the interaction as minor. Colchicine and Deferasirox have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Deferasirox has variable effects on CYP enzymes, mainly inducing CYP3A4 weakly while inhibiting CYP2C8 and CYP1A2. A reduction in colchicine exposure is possible but not well characterized.
How serious is the interaction between Colchicine and Deferasirox?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor colchicine response and adjust dose only if efficacy is lost. No routine adjustment is needed.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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