Drug interactions
Colchicine + Encorafenib
Severity: Moderate
Colchicine and Encorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib has mixed effects on CYP3A4, acting as both an inhibitor and an inducer, so colchicine exposure may rise or fall unpredictably. Raised colchicine levels could cause gastrointestinal, hematologic or neuromuscular toxicity, while reduced levels could blunt gout or FMF control.
What this interaction means in plain words
Colchicine and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colchicine belongs to Genitourinary; Encorafenib belongs to Oncology.
Why it happens
Encorafenib exerts both inhibition and induction of CYP3A4, altering colchicine metabolism in an unpredictable direction.
What to do
Monitor for colchicine toxicity (diarrhea, myalgia, cytopenias) and for loss of efficacy, and adjust the colchicine dose accordingly. Use extra caution in patients with renal or hepatic impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Colchicine with Encorafenib?
MediHelp rates the interaction as moderate. Colchicine and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib has mixed effects on CYP3A4, acting as both an inhibitor and an inducer, so colchicine exposure may rise or fall unpredictably. Raised colchicine levels could cause gastrointestinal, hematologic or neuromuscular toxicity, while reduced levels could blunt gout or FMF control.
How serious is the interaction between Colchicine and Encorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for colchicine toxicity (diarrhea, myalgia, cytopenias) and for loss of efficacy, and adjust the colchicine dose accordingly. Use extra caution in patients with renal or hepatic impairment.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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