Drug interactions
Colchicine + Glecaprevir / pibrentasvir
Severity: Major
Colchicine and Glecaprevir / pibrentasvir: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-glycoprotein and may increase colchicine concentrations. This raises the risk of colchicine toxicity, especially in patients with renal or hepatic impairment.
What this interaction means in plain words
Colchicine and Glecaprevir / pibrentasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of intestinal and hepatic P-gp reduces colchicine efflux and clearance.
What to do
Avoid in renal or hepatic impairment. Otherwise reduce the colchicine dose per labeling and monitor for toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Frequently asked questions
Can I take Colchicine with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as major. Colchicine and Glecaprevir / pibrentasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Glecaprevir and pibrentasvir inhibit P-glycoprotein and may increase colchicine concentrations. This raises the risk of colchicine toxicity, especially in patients with renal or hepatic impairment.
How serious is the interaction between Colchicine and Glecaprevir / pibrentasvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in renal or hepatic impairment. Otherwise reduce the colchicine dose per labeling and monitor for toxicity.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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