Drug interactions
Colchicine + Griseofulvin
Severity: Minor
Colchicine and Griseofulvin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin is a weak inducer of CYP3A4, so it could lower colchicine exposure and reduce its effect in gout flares or prophylaxis. The clinical impact is not well characterized and is likely modest.
What this interaction means in plain words
Colchicine and Griseofulvin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Colchicine belongs to Genitourinary; Griseofulvin belongs to Anti Fungals.
Why it happens
Possible weak induction of CYP3A4 (and possibly P-gp) by griseofulvin, increasing colchicine clearance.
What to do
No empirical dose change is needed; assess gout control and consider a higher colchicine dose only if flares persist.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Griseofulvin
Frequently asked questions
Can I take Colchicine with Griseofulvin?
MediHelp rates the interaction as minor. Colchicine and Griseofulvin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Griseofulvin is a weak inducer of CYP3A4, so it could lower colchicine exposure and reduce its effect in gout flares or prophylaxis. The clinical impact is not well characterized and is likely modest.
How serious is the interaction between Colchicine and Griseofulvin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; assess gout control and consider a higher colchicine dose only if flares persist.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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