Drug interactions
Colchicine + Hydrocortisone
Severity: Minor
Colchicine and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone could theoretically lower colchicine exposure through weak CYP3A4 induction, but no meaningful clinical effect is documented.
What this interaction means in plain words
Colchicine and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Colchicine belongs to Genitourinary; Hydrocortisone belongs to Endocrine.
Why it happens
Theoretical weak CYP3A4 induction by hydrocortisone.
What to do
No dose change needed; monitor gout or inflammatory response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Frequently asked questions
Can I take Colchicine with Hydrocortisone?
MediHelp rates the interaction as minor. Colchicine and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrocortisone could theoretically lower colchicine exposure through weak CYP3A4 induction, but no meaningful clinical effect is documented.
How serious is the interaction between Colchicine and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change needed; monitor gout or inflammatory response.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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