Drug interactions
Colchicine + Lumacaftor / ivacaftor
Severity: Moderate
Colchicine and Lumacaftor / ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is a strong CYP3A inducer and may lower colchicine concentrations, causing loss of effect. Lumacaftor/ivacaftor may also affect P-gp, so the net effect is variable.
What this interaction means in plain words
Colchicine and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A induction by lumacaftor increases colchicine metabolism.
What to do
Monitor for reduced colchicine efficacy and adjust the dose to clinical response. Watch for toxicity if lumacaftor/ivacaftor is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Frequently asked questions
Can I take Colchicine with Lumacaftor / ivacaftor?
MediHelp rates the interaction as moderate. Colchicine and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor is a strong CYP3A inducer and may lower colchicine concentrations, causing loss of effect. Lumacaftor/ivacaftor may also affect P-gp, so the net effect is variable.
How serious is the interaction between Colchicine and Lumacaftor / ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced colchicine efficacy and adjust the dose to clinical response. Watch for toxicity if lumacaftor/ivacaftor is stopped.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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