Drug interactions
Colchicine + Telotristat ethyl
Severity: Moderate
Colchicine and Telotristat ethyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telotristat may induce CYP3A4 and lower the exposure of sensitive substrates. This could reduce colchicine efficacy.
What this interaction means in plain words
Colchicine and Telotristat ethyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 by telotristat increases colchicine metabolism.
What to do
Monitor for loss of colchicine efficacy and titrate the dose to response within labeled limits. Reassess when telotristat is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Frequently asked questions
Can I take Colchicine with Telotristat ethyl?
MediHelp rates the interaction as moderate. Colchicine and Telotristat ethyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telotristat may induce CYP3A4 and lower the exposure of sensitive substrates. This could reduce colchicine efficacy.
How serious is the interaction between Colchicine and Telotristat ethyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of colchicine efficacy and titrate the dose to response within labeled limits. Reassess when telotristat is stopped.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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