Drug interactions
Colestipol + Doxycycline
Severity: Moderate
Colestipol and Doxycycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colestipol is a bile acid sequestrant that can bind oral doxycycline in the gut and reduce its absorption. This may lower doxycycline levels and reduce antibacterial efficacy.
What this interaction means in plain words
Colestipol and Doxycycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colestipol belongs to Cardiovascular; Doxycycline belongs to Anti Bacterial.
Why it happens
Colestipol binds doxycycline in the gastrointestinal lumen, decreasing its absorption.
What to do
Give oral doxycycline at least 1 hour before or 4 hours after colestipol, and monitor clinical response to the antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Other interactions of Colestipol
- Amlodipine-hydrochlorothiazide-valsartan + Colestipol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Colestipol Moderate
- Atenolol-chlorthalidone + Colestipol Moderate
- Azilsartan-chlorthalidone + Colestipol Moderate
- Candesartan-hydrochlorothiazide + Colestipol Moderate
- Captopril-hydrochlorothiazide + Colestipol Moderate
Frequently asked questions
Can I take Colestipol with Doxycycline?
MediHelp rates the interaction as moderate. Colestipol and Doxycycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colestipol is a bile acid sequestrant that can bind oral doxycycline in the gut and reduce its absorption. This may lower doxycycline levels and reduce antibacterial efficacy.
How serious is the interaction between Colestipol and Doxycycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral doxycycline at least 1 hour before or 4 hours after colestipol, and monitor clinical response to the antibiotic.
What other medicines interact with Doxycycline?
MediHelp also lists interactions of Doxycycline with, for example, Acitretin, Aminolevulinic acid, Cholera vaccine. The full list is on the Doxycycline page.
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