Drug interactions
Colestipol + Folic acid
Severity: Minor
Colestipol and Folic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bile acid sequestrants such as colestipol can bind folate in the gut and may reduce its absorption. Reported effects on folate status are small and clinically significant deficiency is uncommon.
What this interaction means in plain words
Colestipol and Folic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Colestipol belongs to Cardiovascular; Folic acid belongs to Miscellaneous.
Why it happens
Colestipol binds folic acid in the intestinal lumen, reducing its absorption.
What to do
Give folic acid at least 1 hour before or 4 hours after colestipol. Check folate status only if long-term therapy or deficiency risk is present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Folic acid
- Ethotoin + Folic acid Moderate
- Folic acid + Fosphenytoin Moderate
- Folic acid + Glucarpidase Moderate
- Folic acid + Methotrexate Moderate
- Folic acid + Pafolacianine Moderate
- Folic acid + Phenobarbital Moderate
Other interactions of Colestipol
- Amlodipine-hydrochlorothiazide-valsartan + Colestipol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Colestipol Moderate
- Atenolol-chlorthalidone + Colestipol Moderate
- Azilsartan-chlorthalidone + Colestipol Moderate
- Candesartan-hydrochlorothiazide + Colestipol Moderate
- Captopril-hydrochlorothiazide + Colestipol Moderate
Frequently asked questions
Can I take Colestipol with Folic acid?
MediHelp rates the interaction as minor. Colestipol and Folic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bile acid sequestrants such as colestipol can bind folate in the gut and may reduce its absorption. Reported effects on folate status are small and clinically significant deficiency is uncommon.
How serious is the interaction between Colestipol and Folic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give folic acid at least 1 hour before or 4 hours after colestipol. Check folate status only if long-term therapy or deficiency risk is present.
What other medicines interact with Folic acid?
MediHelp also lists interactions of Folic acid with, for example, Ethotoin, Fosphenytoin, Glucarpidase. The full list is on the Folic acid page.
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