Drug interactions
Colestipol + Hydrochlorothiazide-losartan
Severity: Moderate
Colestipol and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colestipol, a bile acid sequestrant, binds hydrochlorothiazide in the gut and reduces its absorption, which can blunt the diuretic and antihypertensive effect. Losartan absorption may also be reduced to a lesser degree.
What this interaction means in plain words
Colestipol and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colestipol belongs to Cardiovascular; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Anion-exchange resin binds hydrochlorothiazide in the gastrointestinal tract and decreases its oral absorption.
What to do
Give the hydrochlorothiazide-losartan tablet at least 4 hours before or at least 4 to 6 hours after colestipol. Monitor blood pressure if timing cannot be separated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Colestipol
- Amlodipine-hydrochlorothiazide-valsartan + Colestipol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Colestipol Moderate
- Atenolol-chlorthalidone + Colestipol Moderate
- Azilsartan-chlorthalidone + Colestipol Moderate
- Candesartan-hydrochlorothiazide + Colestipol Moderate
- Captopril-hydrochlorothiazide + Colestipol Moderate
Frequently asked questions
Can I take Colestipol with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Colestipol and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colestipol, a bile acid sequestrant, binds hydrochlorothiazide in the gut and reduces its absorption, which can blunt the diuretic and antihypertensive effect. Losartan absorption may also be reduced to a lesser degree.
How serious is the interaction between Colestipol and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the hydrochlorothiazide-losartan tablet at least 4 hours before or at least 4 to 6 hours after colestipol. Monitor blood pressure if timing cannot be separated.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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