Drug interactions
Colistin + Voclosporin
Severity: Major
Colistin and Voclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a calcineurin inhibitor that can cause dose-related nephrotoxicity, and colistin is also nephrotoxic. Together they raise the risk of acute kidney injury and may further reduce kidney function in lupus nephritis patients.
What this interaction means in plain words
Colistin and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Colistin belongs to Anti Bacterial; Voclosporin belongs to Miscellaneous.
Why it happens
Additive nephrotoxicity, with calcineurin inhibitor vasoconstriction combined with direct colistin tubular toxicity.
What to do
Monitor eGFR and serum creatinine closely and reduce or hold voclosporin per labeling if renal function declines. Adjust colistin dose to renal function and avoid it if alternatives exist.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Colistin
- Colistin + Polymyxin b Contraindicated
- Amikacin + Colistin Major
- Amphotericin b deoxycholate + Colistin Major
- Amphotericin b + Colistin Major
- Atracurium + Colistin Major
- Bacitracin + Colistin Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Colistin with Voclosporin?
MediHelp rates the interaction as major. Colistin and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voclosporin is a calcineurin inhibitor that can cause dose-related nephrotoxicity, and colistin is also nephrotoxic. Together they raise the risk of acute kidney injury and may further reduce kidney function in lupus nephritis patients.
How serious is the interaction between Colistin and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor eGFR and serum creatinine closely and reduce or hold voclosporin per labeling if renal function declines. Adjust colistin dose to renal function and avoid it if alternatives exist.
What other medicines interact with Colistin?
MediHelp also lists interactions of Colistin with, for example, Polymyxin b, Amikacin, Amphotericin b deoxycholate. The full list is on the Colistin page.
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