Drug interactions
Conivaptan + Digoxin
Severity: Moderate
Conivaptan and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan may raise digoxin exposure, increasing the risk of digoxin toxicity such as arrhythmias, nausea and visual disturbance. Digoxin has a narrow therapeutic index, so even modest increases can matter.
What this interaction means in plain words
Conivaptan and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Conivaptan inhibits CYP3A4 and may inhibit P-glycoprotein, reducing digoxin clearance and increasing exposure.
What to do
Monitor serum digoxin concentrations and ECG during conivaptan infusion. Reduce the digoxin dose if signs of toxicity or elevated levels appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Conivaptan and Digoxin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Conivaptan with Digoxin?
MediHelp rates the interaction as moderate. Conivaptan and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan may raise digoxin exposure, increasing the risk of digoxin toxicity such as arrhythmias, nausea and visual disturbance. Digoxin has a narrow therapeutic index, so even modest increases can matter.
How serious is the interaction between Conivaptan and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin concentrations and ECG during conivaptan infusion. Reduce the digoxin dose if signs of toxicity or elevated levels appear.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
