Drug interactions
Conivaptan + Lacosamide
Severity: Minor
Conivaptan and Lacosamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a strong CYP3A4 inhibitor, but CYP3A4 is only a minor pathway for lacosamide. Clinically meaningful increases in lacosamide levels are unlikely except in renal or hepatic impairment.
What this interaction means in plain words
Conivaptan and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP3A4 inhibition by conivaptan modestly reduces one minor lacosamide clearance pathway.
What to do
No routine dose change is needed. Monitor for dizziness, ataxia and conduction effects in patients with renal or hepatic impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Frequently asked questions
Can I take Conivaptan with Lacosamide?
MediHelp rates the interaction as minor. Conivaptan and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Conivaptan is a strong CYP3A4 inhibitor, but CYP3A4 is only a minor pathway for lacosamide. Clinically meaningful increases in lacosamide levels are unlikely except in renal or hepatic impairment.
How serious is the interaction between Conivaptan and Lacosamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for dizziness, ataxia and conduction effects in patients with renal or hepatic impairment.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Atazanavir, Carbamazepine. The full list is on the Lacosamide page.
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