Drug interactions
Conivaptan + Modafinil
Severity: Moderate
Conivaptan and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a strong CYP3A4 inhibitor and may increase modafinil exposure. Modafinil effects such as insomnia, anxiety and tachycardia could be intensified. Conivaptan is used short term in hospital settings.
What this interaction means in plain words
Conivaptan and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Conivaptan inhibits CYP3A4, reducing the metabolism of modafinil.
What to do
Monitor for increased modafinil effects during conivaptan infusion and consider temporarily holding or reducing modafinil.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Frequently asked questions
Can I take Conivaptan with Modafinil?
MediHelp rates the interaction as moderate. Conivaptan and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan is a strong CYP3A4 inhibitor and may increase modafinil exposure. Modafinil effects such as insomnia, anxiety and tachycardia could be intensified. Conivaptan is used short term in hospital settings.
How serious is the interaction between Conivaptan and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased modafinil effects during conivaptan infusion and consider temporarily holding or reducing modafinil.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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