Drug interactions
Conivaptan + Upadacitinib
Severity: Moderate
Conivaptan and Upadacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a strong CYP3A4 inhibitor and may increase upadacitinib exposure, with a higher risk of infections and cytopenias.
What this interaction means in plain words
Conivaptan and Upadacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Conivaptan inhibits CYP3A4, reducing upadacitinib metabolism.
What to do
Apply reduced upadacitinib dosing per labeling when strong CYP3A4 inhibitors are used. Monitor for infection and laboratory abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Upadacitinib Contraindicated
Frequently asked questions
Can I take Conivaptan with Upadacitinib?
MediHelp rates the interaction as moderate. Conivaptan and Upadacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan is a strong CYP3A4 inhibitor and may increase upadacitinib exposure, with a higher risk of infections and cytopenias.
How serious is the interaction between Conivaptan and Upadacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Apply reduced upadacitinib dosing per labeling when strong CYP3A4 inhibitors are used. Monitor for infection and laboratory abnormalities.
What other medicines interact with Upadacitinib?
MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.
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