Drug interactions
Conjugated estrogens + Nevirapine
Severity: Moderate
Conjugated estrogens and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may reduce estrogen exposure by inducing CYP3A4, weakening symptom relief. In women using estrogens for contraception-like purposes, reduced hormone effect is also a concern.
What this interaction means in plain words
Conjugated estrogens and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nevirapine induces CYP3A4 metabolism of estrogens.
What to do
Monitor for return of menopausal symptoms and titrate the estrogen dose to clinical response. Use non-hormonal contraception if contraception is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Conjugated estrogens with Nevirapine?
MediHelp rates the interaction as moderate. Conjugated estrogens and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may reduce estrogen exposure by inducing CYP3A4, weakening symptom relief. In women using estrogens for contraception-like purposes, reduced hormone effect is also a concern.
How serious is the interaction between Conjugated estrogens and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for return of menopausal symptoms and titrate the estrogen dose to clinical response. Use non-hormonal contraception if contraception is needed.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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