Drug interactions
Corticotropin + Cyclosporin
Severity: Moderate
Corticotropin and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticotropin stimulates endogenous corticosteroid production, and corticosteroids can change cyclosporine concentrations, while cyclosporine may raise corticosteroid levels. The result is variable cyclosporine exposure and additive immunosuppression and adverse effects.
What this interaction means in plain words
Corticotropin and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Corticotropin belongs to Endocrine; Cyclosporin belongs to Miscellaneous.
Why it happens
Corticosteroid effects on CYP3A4 and P-gp alter cyclosporine levels, and cyclosporine inhibits steroid metabolism.
What to do
Monitor cyclosporine trough levels and renal function, and watch for steroid toxicity and infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Corticotropin
Frequently asked questions
Can I take Corticotropin with Cyclosporin?
MediHelp rates the interaction as moderate. Corticotropin and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticotropin stimulates endogenous corticosteroid production, and corticosteroids can change cyclosporine concentrations, while cyclosporine may raise corticosteroid levels. The result is variable cyclosporine exposure and additive immunosuppression and adverse effects.
How serious is the interaction between Corticotropin and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and renal function, and watch for steroid toxicity and infection.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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