Drug interactions
Corticotropin + Eprosartan-hydrochlorothiazide
Severity: Moderate
Corticotropin and Eprosartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticotropin stimulates adrenal steroids with mineralocorticoid activity, which promotes potassium loss and may worsen thiazide-induced hypokalemia. Fluid retention may also oppose blood pressure control.
What this interaction means in plain words
Corticotropin and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Corticotropin belongs to Endocrine; Eprosartan-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Adrenal corticosteroid release increases renal potassium excretion, adding to thiazide-induced potassium wasting.
What to do
Monitor serum potassium and blood pressure during corticotropin therapy. Give potassium supplementation if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Corticotropin
Frequently asked questions
Can I take Corticotropin with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Corticotropin and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticotropin stimulates adrenal steroids with mineralocorticoid activity, which promotes potassium loss and may worsen thiazide-induced hypokalemia. Fluid retention may also oppose blood pressure control.
How serious is the interaction between Corticotropin and Eprosartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure during corticotropin therapy. Give potassium supplementation if needed.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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