Drug interactions
Corticotropin + Glipizide-metformin
Severity: Moderate
Corticotropin and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticotropin stimulates cortisol release, which raises blood glucose and can reduce the effectiveness of antidiabetic drugs. Hyperglycemia may require temporary intensification of therapy.
What this interaction means in plain words
Corticotropin and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Corticotropin belongs to Endocrine; Glipizide-metformin belongs to Endocrine.
Why it happens
Corticotropin-induced glucocorticoid excess increases hepatic gluconeogenesis and insulin resistance, opposing the glucose-lowering drugs.
What to do
Monitor blood glucose frequently during corticotropin courses and increase antidiabetic doses if needed. Reduce doses again, watching for hypoglycemia, when corticotropin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Corticotropin and Glipizide-metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glipizide-metformin
Other interactions of Corticotropin
Frequently asked questions
Can I take Corticotropin with Glipizide-metformin?
MediHelp rates the interaction as moderate. Corticotropin and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticotropin stimulates cortisol release, which raises blood glucose and can reduce the effectiveness of antidiabetic drugs. Hyperglycemia may require temporary intensification of therapy.
How serious is the interaction between Corticotropin and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently during corticotropin courses and increase antidiabetic doses if needed. Reduce doses again, watching for hypoglycemia, when corticotropin is stopped.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
