Drug interactions
Corticotropin + Insulin degludec
Severity: Moderate
Corticotropin and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticotropin stimulates cortisol release, which raises blood glucose and can reduce the effectiveness of insulin degludec. Higher insulin doses may be needed during treatment.
What this interaction means in plain words
Corticotropin and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Corticotropin belongs to Endocrine; Insulin degludec belongs to Endocrine.
Why it happens
Cortisol increases gluconeogenesis and insulin resistance, opposing insulin action.
What to do
Monitor blood glucose more frequently during corticotropin therapy and increase insulin degludec as needed, then reduce again when it is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec
Other interactions of Corticotropin
Frequently asked questions
Can I take Corticotropin with Insulin degludec?
MediHelp rates the interaction as moderate. Corticotropin and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticotropin stimulates cortisol release, which raises blood glucose and can reduce the effectiveness of insulin degludec. Higher insulin doses may be needed during treatment.
How serious is the interaction between Corticotropin and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently during corticotropin therapy and increase insulin degludec as needed, then reduce again when it is stopped.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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