Drug interactions
Corticotropin + Metformin-repaglinide
Severity: Moderate
Corticotropin and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticotropin stimulates cortisol release, and the resulting glucocorticoid excess raises blood glucose. This can reduce the effectiveness of metformin and repaglinide and cause hyperglycemia.
What this interaction means in plain words
Corticotropin and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Corticotropin belongs to Endocrine; Metformin-repaglinide belongs to Endocrine.
Why it happens
Corticotropin-induced cortisol increases hepatic gluconeogenesis and insulin resistance, opposing the glucose-lowering drugs.
What to do
Monitor blood glucose during corticotropin therapy and increase antidiabetic treatment as needed. Watch for hypoglycemia when corticotropin is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Corticotropin
Frequently asked questions
Can I take Corticotropin with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Corticotropin and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticotropin stimulates cortisol release, and the resulting glucocorticoid excess raises blood glucose. This can reduce the effectiveness of metformin and repaglinide and cause hyperglycemia.
How serious is the interaction between Corticotropin and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during corticotropin therapy and increase antidiabetic treatment as needed. Watch for hypoglycemia when corticotropin is withdrawn.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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