Drug interactions
Corticotropin + Ofloxacin
Severity: Moderate
Corticotropin and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones carry a risk of tendinitis and tendon rupture, and corticosteroid exposure raises that risk further. Corticotropin stimulates endogenous cortisol release, so a similar additive effect is expected, especially in older patients.
What this interaction means in plain words
Corticotropin and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Corticotropin belongs to Endocrine; Ofloxacin belongs to Anti Bacterial.
Why it happens
Additive tendon toxicity from fluoroquinolone effects on tendon tissue and corticosteroid-mediated collagen impairment.
What to do
Counsel the patient to stop the fluoroquinolone and report tendon pain or swelling immediately. Consider a non-quinolone antibiotic in older patients or those on prolonged corticotropin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Corticotropin
Frequently asked questions
Can I take Corticotropin with Ofloxacin?
MediHelp rates the interaction as moderate. Corticotropin and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones carry a risk of tendinitis and tendon rupture, and corticosteroid exposure raises that risk further. Corticotropin stimulates endogenous cortisol release, so a similar additive effect is expected, especially in older patients.
How serious is the interaction between Corticotropin and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to stop the fluoroquinolone and report tendon pain or swelling immediately. Consider a non-quinolone antibiotic in older patients or those on prolonged corticotropin.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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