Drug interactions
Corticotropin + Rocuronium
Severity: Moderate
Corticotropin and Rocuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids, and corticotropin through endogenous steroid release, have been associated with acute myopathy when combined with nondepolarizing neuromuscular blockers, especially during prolonged ICU use. This may cause persistent weakness and delay ventilator weaning.
What this interaction means in plain words
Corticotropin and Rocuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Corticotropin belongs to Endocrine; Rocuronium belongs to Musculoskeletal.
Why it happens
Probable additive myotoxicity with steroid exposure; the exact mechanism is not fully established.
What to do
Limit the duration and dose of neuromuscular blockade where possible. Monitor for persistent weakness and creatine kinase during prolonged coadministration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rocuronium
Other interactions of Corticotropin
Frequently asked questions
Can I take Corticotropin with Rocuronium?
MediHelp rates the interaction as moderate. Corticotropin and Rocuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids, and corticotropin through endogenous steroid release, have been associated with acute myopathy when combined with nondepolarizing neuromuscular blockers, especially during prolonged ICU use. This may cause persistent weakness and delay ventilator weaning.
How serious is the interaction between Corticotropin and Rocuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the duration and dose of neuromuscular blockade where possible. Monitor for persistent weakness and creatine kinase during prolonged coadministration.
What other medicines interact with Rocuronium?
MediHelp also lists interactions of Rocuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Rocuronium page.
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