Drug interactions
Cortisone + Everolimus
Severity: Minor
Cortisone and Everolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cortisone is a weak CYP3A4 inducer at most, and corticosteroids are commonly combined with everolimus in transplant regimens. Any reduction in everolimus exposure is small and not clinically significant for typical replacement or short-course doses.
What this interaction means in plain words
Cortisone and Everolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak induction of CYP3A4 by corticosteroids.
What to do
No routine adjustment is needed; check everolimus trough levels if high steroid doses are started or stopped in transplant patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Cortisone with Everolimus?
MediHelp rates the interaction as minor. Cortisone and Everolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cortisone is a weak CYP3A4 inducer at most, and corticosteroids are commonly combined with everolimus in transplant regimens. Any reduction in everolimus exposure is small and not clinically significant for typical replacement or short-course doses.
How serious is the interaction between Cortisone and Everolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; check everolimus trough levels if high steroid doses are started or stopped in transplant patients.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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