Drug interactions
Cortisone + Fluconazole
Severity: Moderate
Cortisone and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may reduce metabolism of corticosteroids and increase systemic exposure. This could increase glucocorticoid effects such as fluid retention, hyperglycemia and adrenal suppression, mainly with prolonged use.
What this interaction means in plain words
Cortisone and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 and reduced clearance of corticosteroids by fluconazole.
What to do
Monitor for corticosteroid excess such as blood glucose and blood pressure changes during prolonged coadministration. Reduce the corticosteroid dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cortisone and Fluconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Cortisone with Fluconazole?
MediHelp rates the interaction as moderate. Cortisone and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole may reduce metabolism of corticosteroids and increase systemic exposure. This could increase glucocorticoid effects such as fluid retention, hyperglycemia and adrenal suppression, mainly with prolonged use.
How serious is the interaction between Cortisone and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid excess such as blood glucose and blood pressure changes during prolonged coadministration. Reduce the corticosteroid dose if needed.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
