Drug interactions
Cortisone + Glipizide
Severity: Moderate
Cortisone and Glipizide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cortisone is a glucocorticoid that raises blood glucose and can offset the effect of glipizide. Hyperglycemia may be marked with systemic courses, particularly after meals.
What this interaction means in plain words
Cortisone and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoids increase hepatic gluconeogenesis and peripheral insulin resistance, opposing sulfonylurea action.
What to do
Monitor blood glucose more frequently during corticosteroid therapy and raise the glipizide dose or add insulin if needed. Reduce the antidiabetic dose again when the steroid is tapered to avoid hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Frequently asked questions
Can I take Cortisone with Glipizide?
MediHelp rates the interaction as moderate. Cortisone and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cortisone is a glucocorticoid that raises blood glucose and can offset the effect of glipizide. Hyperglycemia may be marked with systemic courses, particularly after meals.
How serious is the interaction between Cortisone and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently during corticosteroid therapy and raise the glipizide dose or add insulin if needed. Reduce the antidiabetic dose again when the steroid is tapered to avoid hypoglycemia.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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