Drug interactions
Cortisone + Hydrochlorothiazide-irbesartan
Severity: Moderate
Cortisone and Hydrochlorothiazide-irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cortisone has some mineralocorticoid activity and promotes renal potassium loss, which adds to the potassium-wasting effect of hydrochlorothiazide. Hypokalemia may develop, and the irbesartan component only partly offsets it.
What this interaction means in plain words
Cortisone and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal potassium excretion from thiazide diuresis and corticosteroid mineralocorticoid effect.
What to do
Monitor serum potassium and magnesium periodically during combined use, especially with prolonged or high-dose corticosteroid therapy. Replace potassium if levels fall.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Cortisone with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Cortisone and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cortisone has some mineralocorticoid activity and promotes renal potassium loss, which adds to the potassium-wasting effect of hydrochlorothiazide. Hypokalemia may develop, and the irbesartan component only partly offsets it.
How serious is the interaction between Cortisone and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium periodically during combined use, especially with prolonged or high-dose corticosteroid therapy. Replace potassium if levels fall.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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