Drug interactions
Cortisone + Metolazone
Severity: Moderate
Cortisone and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cortisone has mineralocorticoid activity and promotes renal potassium loss. With metolazone, hypokalemia and other electrolyte disturbances may be enhanced.
What this interaction means in plain words
Cortisone and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal potassium wasting from corticosteroid mineralocorticoid action and thiazide-type diuresis.
What to do
Monitor serum potassium and magnesium, and replace potassium if low. Be especially vigilant in patients on digoxin or with arrhythmia risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Frequently asked questions
Can I take Cortisone with Metolazone?
MediHelp rates the interaction as moderate. Cortisone and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cortisone has mineralocorticoid activity and promotes renal potassium loss. With metolazone, hypokalemia and other electrolyte disturbances may be enhanced.
How serious is the interaction between Cortisone and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, and replace potassium if low. Be especially vigilant in patients on digoxin or with arrhythmia risk.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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