Drug interactions
Cortisone + Temsirolimus
Severity: Minor
Cortisone and Temsirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cortisone is at most a weak CYP3A4 inducer, and significant lowering of temsirolimus exposure is unlikely at usual doses. Corticosteroids are often given with temsirolimus as premedication or supportive care.
What this interaction means in plain words
Cortisone and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak glucocorticoid-mediated CYP3A4 induction.
What to do
No dose adjustment is generally needed. Monitor treatment response if high-dose corticosteroids are used long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Cortisone with Temsirolimus?
MediHelp rates the interaction as minor. Cortisone and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cortisone is at most a weak CYP3A4 inducer, and significant lowering of temsirolimus exposure is unlikely at usual doses. Corticosteroids are often given with temsirolimus as premedication or supportive care.
How serious is the interaction between Cortisone and Temsirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed. Monitor treatment response if high-dose corticosteroids are used long term.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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