Drug interactions
Cosyntropin + Hydrochlorothiazide
Severity: Minor
Cosyntropin and Hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cosyntropin is used as a single diagnostic dose that briefly stimulates cortisol release. Any effect on potassium with hydrochlorothiazide is transient and not clinically meaningful.
What this interaction means in plain words
Cosyntropin and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cosyntropin belongs to Musculoskeletal; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Transient corticosteroid release could add to thiazide potassium loss, but this is theoretical.
What to do
No specific action is required for a single diagnostic test.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cosyntropin and Hydrochlorothiazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydrochlorothiazide
Other interactions of Cosyntropin
Frequently asked questions
Can I take Cosyntropin with Hydrochlorothiazide?
MediHelp rates the interaction as minor. Cosyntropin and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cosyntropin is used as a single diagnostic dose that briefly stimulates cortisol release. Any effect on potassium with hydrochlorothiazide is transient and not clinically meaningful.
How serious is the interaction between Cosyntropin and Hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is required for a single diagnostic test.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
